Feature
Making sure the stem cell quality and safety
MetS is a complicated clinical condition and has emerged as a threatening global epidemic . in safety and efficacy studies . MSCs can improve the various disorders of MetS such as abdominal obesity , hyperglycaemia , hypertriglyceridemia and hypertension , and represent a promising alternative to conventional therapy of the MetS cluster . From the analysis and review of recent works , the superior source of MSCs is from the UC-MSCs , where the cells can be obtained conveniently , less invasively , and have excellent regenerative and immunosuppressive properties .
Metabolic Syndrome ( MetS ) is described as a cluster of metabolic abnormalities categorized as abdominal obesity , dyslipidaemia , hypertension , hypertriglyceridemia , and hyperglycaemia . Patients diagnosed with MetS have a high predisposition for developing cardiovascular complications , diabetes , non-alcoholic fatty liver diseases , bone loss , cancer , and mortality .
Metabolic syndrome , risk factors and current treatment It was hypothesized that a quarter of adults in the world are diagnosed with MetS . These individuals have double the risk of mortality from cardiovascular complications like stroke . Similarly , they are also five times more likely to develop type 2 diabetes . MetS is confirmed when three or more of these symptoms are present in an individual . The causes for MetS are abundant but each has varied impacts based on the demands and availability of these resources in our era . Higher socioeconomic status , sedentary lifestyle , poor diet choices ( or high BMI ) and poor lifestyle choices ( such as smoking ) have the greatest magnitude . Smaller contributions can also be observed from the genetic background , level of education and the heritability of traits prone to MetS development . Mesenchymal stem cell therapy for metabolic syndrome MetS is described as chronic damage from lowgrade inflammation in the body .
Recent evidence suggests that MSC as cell therapy could serve as solutions for the limitations of current therapeutics . This interest is mainly due to their secretion of bioactive metabolites involved in immunomodulation , chemotaxis , apoptotic and antifibrotic functions . Hence , these properties render the MSC a potential candidate for treating degenerative and immunological diseases .
Mesenchymal stem cell therapy for metabolic syndrome The regenerative potential of MSC in repair and renewal has been investigated extensively . MSCs are multipotent progenitor cells able to differentiate into different cell types such as osteocyte , chondrocyte and adipocyte . MSCs are classified to their respective sources , from the bone marrow , adipose tissue , umbilical cord , dental pulp , endometrium , skeletal muscles , liver and pancreas . This subset of MSC has been recently regarded as promising candidates for stem cell-based therapy in treating several other diseases .
MetS is a complicated clinical condition and has emerged as a threatening global epidemic . The current state of medical practices cannot offer solutions for patients diagnosed with this syndrome . It is likely due to the facts that pathophysiology of MetS is complex , and the precise mechanisms linking each condition remain unclear , therefore limiting the progress and development of alternative medicine .
“ After all , a healthy positive lifestyle is what sets you apart from the other . Whether you ’ re carrying a metabolic disorder or syndrome , while stem-cell will help eradicate the hard phase , the sustainable solution is the management of your lifestyle . From the food intake , exercises and good environmental habits , these will evidently help you curb your obesity .” Professor Chua concluded . n
56 ISSUE 6 | 2024 GlobalHealthAsiaPacific . com